F. Hollwedel et G. Kossmehl, A SIMPLE METHOD FOR THE PREPARATION OF NEW ALPHA-OXOACETIC ACID-ESTERS WITH A PLUG-FLOW REACTOR, Synthesis, (9), 1998, pp. 1241-1242
The formation of ethyl -(2-substituted-4,5-dimethoxyphenyl)-2-oxoaceta
tes in high yield, with negligible byproducts, by reaction of 2-substi
tuted 4,5-dimethoxyphenyl bromides with diethyl oxalate using a plug f
low reactor is reported.