COEXISTENCE OF 3 TUMORS OF NEURAL CREST ORIGIN - NEUROFIBROMA, MENINGIOMA, AND UVEAL MALIGNANT-MELANOMA

Objective: To describe the clinical findings in a patient who develope d a neurofibroma, meningioma, and choroidal melanoma. Methods: Clinica l and histopathological findings of the case are reviewed and presente d. Results: The patient had a right superolateral periorbital neurofib roma, a right sphenoid wing meningioma, and a left choroidal juxtapapi llary malignant melanoma. All 3 tumors are derived from neural crest c ells. Conclusions: To our knowledge, this is the first report of a pat ient with this combination of 3 neural crest-derived tumors. This case is most appropriately classified as a complex neurocristopathy, a dis order involving the aberrant and pathological proliferation of multipl e tissues derived from neural crest cells.