M. Hosono et al., RADIOIMMUNODETECTION OF HUMAN LEUKEMIA WITH ANTI-INTERLEUKIN-2 RECEPTOR ANTIBODY IN SEVERE COMBINED IMMUNODEFICIENCY MICE, Nuclear medicine and biology, 22(7), 1995, pp. 869-874
Anti-Tac monoclonal antibody recognizes human interleukin-2 receptor,
which is overexpressed in leukemic cells of most adult T-cell leukemia
(ATL) patients. To examine the potency of anti-Tac for targeting of A
TL, biodistributions of intravenously administered I-125- and In-111-l
abeled anti-Tac were examined in severe combined immunodeficiency (SCI
D) mice inoculated with ATL cells. Significant amounts of radiolabeled
anti-Tac were found in the spleen and thymus. The trafficking of ATL
cells in SCID mice was detected using In-111-oxine-labeled ATL cells.
These results were coincident with the histologically confirmed infilt
ration of ATL cells. The radiolabeled anti-Tac seemed potent for targe
ting of ATL.