Pc. Hobar et al., THE ROLE OF THE DURA IN CRANIAL BONE REGENERATION IN THE IMMATURE ANIMAL, Plastic and reconstructive surgery, 92(3), 1993, pp. 405-410
In an animal model, the effect of transferring mature pericranial tiss
ues to immature animals with cranial bone defects was tested. Isogenei
c guinea pigs of different ages were used: ''infants'' (3-4 weeks) and
''adults'' (>18 months). Bilateral parietal cranial defects were made
in infant guinea pigs and the guinea pigs were divided into three gro
ups. In group 1 (n = 6), the infant periosteum was resected and replac
ed as an autograft on one side (control), and adult periosteum was tra
nsplanted as an isograft on the other (experiment). In group 2 (n = 5)
, dura was used as the variable. In group 3 (n = 5), combined dura and
periosteum were the variables. After 8 weeks, there was complete or n
ear complete bone regeneration in all animals in which infant dura was
present. There was minimal to no bone regeneration in defects in whic
h adult dura was present. Unlike dura, periosteum had little influence
on the capacity of the bone to regenerate.