The prevalence of tooth rotation concomitant with aplasia of nonadjace
nt teeth in uncrowded, nonsyndromic subjects was assessed. The sample
consisted of 1620 subjects (mean age 14 years 9 months). The findings
were compared with the prevalence calculated for a matched control gro
up of 1000 subjects. Rotation of maxillary lateral incisors in subject
s with premolar aplasia and rotation of premolars in subjects presenti
ng with maxillary lateral incisor aplasia were studied. Associations b
etween both tooth position anomalies and tooth aplasia were significan
t (p < 0.01). in addition, the presence of rotated maxillary lateral i
ncisors was also associated with aplasia of the homologous tooth on th
e opposite side of the dental arch; the same result was found for prem
olars. These data suggest a genetic component in the etiology of tooth
malpositions, such as tooth rotation, which may be considered a covar
iable in a complex of genetically controlled dental disturbances, incl
uding tooth aplasia.