POSITRON EMISSION TOMOGRAPHY IN DRUG-EVALUATION - INFLUENCE OF 3 DIFFERENT CATECHOL-O-METHYLTRANSFERASE INHIBITORS ON METABOLISM OF [NCA] 6-[F-18]FLUORO-L-DOPA IN RHESUS-MONKEY

Authors
GUNTHER I PSYLLA M REDDY GN ANTONINI A VONTOBEL P REIST HW ZOLLINGER A NICKLES RJ BEER HF SCHUBIGER PA LEENDERS KL
Citation
I. Gunther et al., POSITRON EMISSION TOMOGRAPHY IN DRUG-EVALUATION - INFLUENCE OF 3 DIFFERENT CATECHOL-O-METHYLTRANSFERASE INHIBITORS ON METABOLISM OF [NCA] 6-[F-18]FLUORO-L-DOPA IN RHESUS-MONKEY, Nuclear medicine and biology, 22(7), 1995, pp. 921-927
Citations number
21
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
22
Issue
7
Year of publication
1995
Pages
921 - 927
Database
ISI
SICI code
0969-8051(1995)22:7<921:PETID->2.0.ZU;2-I
Abstract
We compared the influence of three different catechol-O-methyltransfer ase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabo lism of no-carrier-added (NCA) 6-[F-18]fluoro-L-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptake in the brain and thus improv ed 6-FDOPA uptake measurements using positron emission tomography (PET ). Best results were obtained with Ro 40-7592.