M. Lucas et al., INTERFERON-BETA-1B INHIBITS REACTIVE OXYGEN SPECIES PRODUCTION IN PERIPHERAL-BLOOD MONOCYTES OF PATIENTS WITH RELAPSING-REMITTING MULTIPLE-SCLEROSIS, Neurochemistry international, 33(2), 1998, pp. 101-102
We studied the rate of reactive oxygen species (ROS) production by mon
ocytes 'ex vivo' in a cohort of healthy individuals, in a group of MS
patients undergoing treatment with interferon beta-lb and another grou
p of MS patients who refused treatment with interferon beta-1b. The ra
te of ROS production in healthy individuals was slightly lower than in
non-treated MS patients. The lower rate of ROS production was obtaine
d in monocytes of MS patients treated with interferon beta-1b. These r
esults indicate that the treatment of relapsing-remitting MS patients
with interferon beta-lb rendered the NADPH oxidase of the monocytes le
ss sensitive to trigger reactive oxygen species (ROS). (C) 1998 Elsevi
er Science Ltd. All rights reserved.