COMBINATORIAL CHEMISTRY - FROM PEPTIDES AND PEPTIDOMIMETICS TO SMALL ORGANIC AND HETEROCYCLIC-COMPOUNDS

Authors
NEFZI A DOOLEY C OSTRESH JM HOUGHTEN RA
Citation
A. Nefzi et al., COMBINATORIAL CHEMISTRY - FROM PEPTIDES AND PEPTIDOMIMETICS TO SMALL ORGANIC AND HETEROCYCLIC-COMPOUNDS, Bioorganic & medicinal chemistry letters, 8(17), 1998, pp. 2273-2278
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
17
Year of publication
1998
Pages
2273 - 2278
Database
ISI
SICI code
0960-894X(1998)8:17<2273:CC-FPA>2.0.ZU;2-E
Abstract
Modified dipeptides have been used successfully for the generation of a variety of small organic and heterocyclic combinatorial libraries, i ncluding linear urea, polyamine, hydantoin, thiohydantoin, cyclic urea , cyclic thiourea and bicyclic guanidine. The synthesis and screening results for a number of these libraries are described. The solid phase synthesis of heterocyclic compounds such as diazepine and thiomorphol inone are also described. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.