COMPARISON OF THE INTRINSIC KINASE-ACTIVITY AND SUBSTRATE-SPECIFICITYOF C-ABL AND BCR-ABL

Authors
WU JZJ PHAN W LAM KS
Citation
Jzj. Wu et al., COMPARISON OF THE INTRINSIC KINASE-ACTIVITY AND SUBSTRATE-SPECIFICITYOF C-ABL AND BCR-ABL, Bioorganic & medicinal chemistry letters, 8(17), 1998, pp. 2279-2284
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
17
Year of publication
1998
Pages
2279 - 2284
Database
ISI
SICI code
0960-894X(1998)8:17<2279:COTIKA>2.0.ZU;2-C
Abstract
We studied the intrinsic tyrosine kinase activity and substrate specif icity of c-Abl and Bcr-Abl protein tyrosine kinases (PTKs) using the p eptide substrates discovered from a synthetic combinatorial peptide li brary. Our data indicate that the phosphorylation of these peptides by Bcr-Abl was consistently stronger than that by c-Abl. Bcr-Abl also sh owed substrate preference towards those peptides with one or more posi tive charges. (C) 1998 Elsevier Science Ltd. All rights reserved.