SOLID-PHASE SYNTHESIS OF A LIBRARY OF PIPERAZINEDIONES AND DIAZEPINEDIONES VIA KAISER OXIME RESIN

Authors
SMITH RA BOBKO MA LEE W
Citation
Ra. Smith et al., SOLID-PHASE SYNTHESIS OF A LIBRARY OF PIPERAZINEDIONES AND DIAZEPINEDIONES VIA KAISER OXIME RESIN, Bioorganic & medicinal chemistry letters, 8(17), 1998, pp. 2369-2374
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
17
Year of publication
1998
Pages
2369 - 2374
Database
ISI
SICI code
0960-894X(1998)8:17<2369:SSOALO>2.0.ZU;2-9
Abstract
A combinatorial library of piperazinediones has been prepared by autom ated parallel solid-phase synthesis. The five-step reaction protocol m akes use of Kaiser oxime resin, to enable cleavage from the polymeric support concomitant with an intramolecular displacement reaction, unde r very mild conditions. The methodology was also successfully extended to the preparation of the seven-membered ring homologs, diazepinedion es. (C) 1998 Elsevier Science Ltd. All rights reserved.