A MIXED RESIN BED FOR THE QUENCHING AND PURIFICATION OF TETRABUTYLAMMONIUM FLUORIDE MEDIATED DESILYLATING REACTIONS

Authors
PARLOW JJ VAZQUEZ ML FLYNN DL
Citation
Jj. Parlow et al., A MIXED RESIN BED FOR THE QUENCHING AND PURIFICATION OF TETRABUTYLAMMONIUM FLUORIDE MEDIATED DESILYLATING REACTIONS, Bioorganic & medicinal chemistry letters, 8(17), 1998, pp. 2391-2394
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
17
Year of publication
1998
Pages
2391 - 2394
Database
ISI
SICI code
0960-894X(1998)8:17<2391:AMRBFT>2.0.ZU;2-T
Abstract
A polymer-bound calcium sulfonate resin is prepared and used to seques ter tetrabutylammonium fluoride. The simultaneous use of the calcium s ulfonate resin with a sulfonic acid resin is used for the quenching an d purification of desilylating reactions involving tetrabutylammonium fluoride as the reagent. Employment of this resin workup technique eli minates the need for a liquid-phase extractive protocol allowing the p rocedure to be easily automated. (C) 1998 Elsevier Science Ltd. All ri ghts reserved.