CONSTRUCTION OF A FAMILY OF BIPHENYL COMBINATORIAL LIBRARIES - STRUCTURE-ACTIVITY STUDIES UTILIZING LIBRARIES OF MIXTURES

Authors
NEUSTADT BR SMITH EM LINDO N NECHUTA T BRONNENKANT A WU A ARMSTRONG L KUMAR C
Citation
Br. Neustadt et al., CONSTRUCTION OF A FAMILY OF BIPHENYL COMBINATORIAL LIBRARIES - STRUCTURE-ACTIVITY STUDIES UTILIZING LIBRARIES OF MIXTURES, Bioorganic & medicinal chemistry letters, 8(17), 1998, pp. 2395-2398
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
17
Year of publication
1998
Pages
2395 - 2398
Database
ISI
SICI code
0960-894X(1998)8:17<2395:COAFOB>2.0.ZU;2-U
Abstract
A set of biphenyl aminoacid building blocks has been synthesized. Thes e were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this librar y as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several i mportant features of combinatorial libraries. (C) 1998 Elsevier Scienc e Ltd. All rights reserved.