REGULATION OF GENE-EXPRESSION BY TRANSSYNAPTIC ACTIVITY - A ROLE FOR THE TRANSCRIPTION FACTOR NF-KAPPA-B

Earlier studies in the sympathetic ganglion have led to the proposal t hat adaptation of transcription to trans-synaptic activity is controll ed by a signal transduction pathway featuring a transcription factor w hich translocates to the nucleus upon its release from the post-synapt ic membrane by after-hyperpolarization. In light of recent progress, i t is proposed here that NF-kappa B constitutes the postulated transcri ption factor. ((C)Elsevier, Paris).