TRANSCRIPTIONAL PATHWAYS FOR SYNAPSE-SPECIFIC, NEUREGULIN-INDUCED ANDELECTRICAL ACTIVITY-DEPENDENT TRANSCRIPTION

Innervation-dependent expression of acetylcholine receptor (AChR) gene s in skeletal muscle is mediated by multiple transcriptional pathways. One pathway leads to activation of AChR genes selectively in synaptic nuclei and requires an Ets binding site that binds GABP A second path way leads to repression of AChR transcription in nuclei throughout the myofiber and requires inactivation of E-box-binding proteins, includi ng myogenic bHLH proteins. Taken together, these studies indicate that separate pathways regulate innervation-dependent transcription. ((C)E lsevier, Paris).