TRKA ANTAGONISTS DECREASE NGF-INDUCED CHAT ACTIVITY IN-VITRO AND MODULATE CHOLINERGIC SYNAPTIC NUMBER IN-VIVO

Authors
DEBEIR T SARAGOVI HU CUELLO AC
Citation
T. Debeir et al., TRKA ANTAGONISTS DECREASE NGF-INDUCED CHAT ACTIVITY IN-VITRO AND MODULATE CHOLINERGIC SYNAPTIC NUMBER IN-VIVO, J PHYSL-PAR, 92(3-4), 1998, pp. 205-208
Citations number
17
Categorie Soggetti
Physiology,Neurosciences
Journal title
JOURNAL OF PHYSIOLOGY-PARIS
ISSN journal
09284257 → ACNP
Volume
92
Issue
3-4
Year of publication
1998
Pages
205 - 208
Database
ISI
SICI code
0928-4257(1998)92:3-4<205:TADNCA>2.0.ZU;2-P
Abstract
Cholinergic neurons are known to respond in vivo to the administration of nerve growth factor (NGF) by a prominent and selective increase of choline acetyl transferase activity and by cholinergic synaptogenesis in the rat brain. By using a synthetic TrkA antagonist we demonstrate d that endogenously produced NGF is involved in the continual re-model ing of cholinergic neuronal connections during adulthood, acting throu gh TrkA receptors. ((C)Elsevier, Paris).