THE ROLE OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS IN ANTINOCICEPTION - EFFECTS OF ABT-594

Authors
DECKER MW CURZON P HOLLADAY MW NIKKEL AL BITNER RS BANNON AW DONNELLYROBERTS DL PUTTFARCKEN PS KUNTZWEILER TA BRIGGS CA WILLIAMS M ARNERIC SP
Citation
Mw. Decker et al., THE ROLE OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS IN ANTINOCICEPTION - EFFECTS OF ABT-594, J PHYSL-PAR, 92(3-4), 1998, pp. 221-224
Citations number
17
Categorie Soggetti
Physiology,Neurosciences
Journal title
JOURNAL OF PHYSIOLOGY-PARIS
ISSN journal
09284257 → ACNP
Volume
92
Issue
3-4
Year of publication
1998
Pages
221 - 224
Database
ISI
SICI code
0928-4257(1998)92:3-4<221:TRONNA>2.0.ZU;2-O
Abstract
ABT-594, a nicotinic acetylcholine receptor agonist, has antinocicepti ve effects in rat models of acute thermal, persistent chemical, and ne uropathic pain. Direct injection of ABT-594 into the nucleus raphe mag nus (NRM) is antinociceptive in a thermal threshold test and destructi on of serotonergic neurons in the NRM attenuates the effect of systemi c ABT-594. However, lidocaine-inactivation of the NRM prevents the ant inociceptive effect of systemic (-)-nicotine bur not that of systemic ABT-594. ((C)Elsevier, Paris).