SCANNING MUTAGENESIS OF TRANSMEMBRANE DOMAIN-3 OF THE M1 MUSCARINIC ACETYLCHOLINE-RECEPTOR

Authors
HULME EC LU ZL
Citation
Ec. Hulme et Zl. Lu, SCANNING MUTAGENESIS OF TRANSMEMBRANE DOMAIN-3 OF THE M1 MUSCARINIC ACETYLCHOLINE-RECEPTOR, J PHYSL-PAR, 92(3-4), 1998, pp. 269-274
Citations number
15
Categorie Soggetti
Physiology,Neurosciences
Journal title
JOURNAL OF PHYSIOLOGY-PARIS
ISSN journal
09284257 → ACNP
Volume
92
Issue
3-4
Year of publication
1998
Pages
269 - 274
Database
ISI
SICI code
0928-4257(1998)92:3-4<269:SMOTDO>2.0.ZU;2-7
Abstract
Scanning mutagenesis of transmembrane domain 3 of the M1 muscarinic ac etylcholine receptor has revealed a highly-differentiated a-helical st ructure. Lipid-facing residues are distinguished from a patch of resid ues which selectively stabilise the ground state of the receptor, and from a band of amino acids extending the full length of the helix, whi ch contribute to the active agonist-receptor-aa protein complex. The m ost important residues are strongly conserved in the GPCR superfamily. ((C)Elsevier, Paris).