CHOLINERGIC EXCITATION INDUCES ACTIVITY-DEPENDENT ELECTROPHYSIOLOGICAL AND TRANSCRIPTIONAL RESPONSES IN HIPPOCAMPAL SLICES

To explore the correlations between short-term neurophysiological even ts initiated by over-activation of acetylcholine receptors, and long-l asting changes in brain function; we combined electrophysiology and PC R-based measurements in hippocampal slices or live mice subjected to s tress or drug-induced cholinergic activation. Our findings reveal a co mmon cascade of neuronal events resulting in delayed suppression of ch olinergic transmission. ((C)Elsevier, Paris).