WAVE-PROPAGATION IN CARDIAC TISSUE AND EFFECTS OF INTRACELLULAR CALCIUM DYNAMICS (COMPUTER-SIMULATION STUDY)

Authors
CHUDIN E GARFINKEL A WEISS J KARPLUS W KOGAN B
Citation
E. Chudin et al., WAVE-PROPAGATION IN CARDIAC TISSUE AND EFFECTS OF INTRACELLULAR CALCIUM DYNAMICS (COMPUTER-SIMULATION STUDY), Progress in Biophysics and Molecular Biology, 69(2-3), 1998, pp. 225-236
Citations number
16
Categorie Soggetti
Biophysics,Biology
Journal title
Progress in Biophysics and Molecular Biology → ACNP
ISSN journal
00796107
Volume
69
Issue
2-3
Year of publication
1998
Pages
225 - 236
Database
ISI
SICI code
0079-6107(1998)69:2-3<225:WICTAE>2.0.ZU;2-Z
Abstract
Computer simulation using Luo-Rudy I1 model of ventricular myocyte sho wed that intracellular calcium dynamics become irregular in case of hi gh rate stimulation. This causes the transition from stationary to non stationary spiral wave and its breakup in 2D model of cardiac tissue. Obtained results suggest how ventricular fibrillation may occur due to the abnormalities of intracellular calcium dynamics. The short review of existing cardiac cell models with calcium dynamics is presented. ( C) 1998 Elsevier Science Ltd. All rights reserved.