FAMILIAL HAIRY-CELL LEUKEMIA - A HLA-LINKED DISEASE OR FARMERS-LINKEDDISEASE

In the 16 cases of familial HCL published, different HLA have been fou nd. Although specific HLA antigens were found to have the same structu re in some cases that suggests a genetic predisposition to HCL. Enviro nmental factors, specifically farming labours, were implicated in too. We add two cases (father and son, both farmers), Their HLA haplotype has not been described, but the type A2Bw4Bw6 and awe, presented in fa ther and/or son, have been.