RENAL-ARTERY CLIPPING ATTENUATES THE PROGRESSION OF ADRIAMYCIN NEPHROPATHY

This study was designed to analyze the impact of diminished renal perf usion pressure due to renal clipping on the rat model of adriamycin ne phropathy. Male Wistar rats, divided into four groups (n = 9 per group ) were injected with saline as control (C), adriamycin 3 ml/kg (Ad), s aline with the left renal artery clipped (Rv), and adriamycin plus cli p (AdRv). After 24 weeks mean arterial pressure (MAP), inulin, and p-a minohippurate (PAH) clearances were performed to evaluate renal functi on. Morphologic analysis included histologic criteria of percentage of glomerulosclerosis and tubulointerstitial lesion index (TILI). The MA P (mm Hg) was similar between Rv (143 +/- 13) and AdRv (154 +/- 20), b ut higher (P < .05) than C (120 +/- 8) and Ad (124 +/- 11). Inulin cle arance (mL/min/100 g) in Ad (0.2 +/- 0.05) was smaller than in C (0.53 +/- 0.17) and Rv (0.4 +/- 0.01) (P < .05), and was at an intermediate level in AdRv (0.33 +/- 0.2). The level of PAH (mL/min/100 g) was nor mal at 1.76 in C, and diminished more in Ad (0.58) than in Rv (1.06) a nd AdRv (1.18) (P < .05). Both Ad and the AdRv nonclipped kidneys had the highest degree of glomerulosclerosis (33% and 25%) and TILI (7% an d 8%), respectively, compared with C and Rv (both 0%), whereas the cli pped kidneys displayed intermediate degrees (9% and 5%) (P < .05 v non clipped). The data suggest that diminished perfusion pressure of the c lipped kidney, by decreasing the intraglomerular pressure, protects th e glomerulus from damage and attenuates the evolution of adriamycin ne phropathy. Am J Hypertens 1998;11:1124-1128 (C) 1998 American Journal of Hypertension, Ltd.