MULTIVARIATE-ANALYSIS RESULTS OF RADIOTHERAPY FOR LARYNGEAL-CANCER

We assess the impact of radiotherapy in the treatment of laryngeal can cer and evaluate the value of the standard dose (linear quadratic plus time model) and other variables to predict tumor control and survival . Between 1972 and 1989, 80 patients with laryngeal cancer received co mprehensive radiotherapy. Patients with stage I laryngeal glottic canc er (T1-N0-M0) were excluded from this study. Mean follow-up was 15 mon ths (range 4 to 181). The mean age was 64.8 years (range 40 to 92). St andard dose varied from 32.65 to 81.81 Gy (mean 66.78). The 5-year ove rall survival and tumor-specific survival rates were 44.9 +/- 5.8% and 51.4 +/- 5.9%, respectively. Five-year local control and locoregional control rates were 66.4 +/- 5.7% and 61.9 +/- 5.8%, respectively. Mul tivariate analysis showed that local control was significantly predict ed by T stage (p = .032), but not by standard dose (p = .906). Indepen dently significant factors predicting tumor-specific survival included stage (p = .006), site (p = .019), and age (p = .001). Local control and survival were significantly predicted by the TNM-staging classific ation. The standard dose did not predict local recurrence or survival. (C) 1993 John Wiley & Sons, Inc.