Sr. Hintz et al., STATIONARY HEADBAND FOR CLINICAL TIME-OF-FLIGHT OPTICAL IMAGING AT THE BEDSIDE, Photochemistry and photobiology, 68(3), 1998, pp. 361-369
Conventional brain-imaging modalities may be limited by high cost, dif
ficulty of bedside use, noncontinuous operation, invasiveness or an in
ability to obtain measurements of tissue function, such as oxygenation
during stroke. Our goal was to develop a bedside clinical device able
to generate continuous, noninvasive, tomographic images of the brain
using low-power nonionizing optical radiation. We modified an existing
stage-based time-of-flight optical tomography system to allow imaging
of patients under clinical conditions. First, a stationary headband c
onsisting of thin, flexible optical fibers was constructed. The headba
nd was then calibrated and tested, including an assessment of fiber le
ngths, the existing system software was modified to collect headband d
ata and to perform simultaneous collection of data and image reconstru
ction, and the existing hardware was modified to scan optically using
this headband. The headband was tested on resin models and allowed for
the generation of tomographic images in vitro; the headband was teste
d on critically ill infants and allowed for optical tomographic images
of the neonatal brain to be obtained irt vivo.