Purpose. We compared the repeatability and accuracy of four commercial
ly available videokeratography instruments and a manual keratometer. M
ethods. Ten optometry students and two university employees who had no
history of rigid contact lens wear and no soft contact lens wear with
in 6 months of the study were measured. Two independent measurements w
ere taken on the right eyes only using the Alcon EyeMap EH-290 topogra
phy system (both manual and automatic focus), the EyeSys System 2000 c
orneal topography system, the Humphrey Mastervue topography system, th
e Humphrey Atlas topography system, and a Marco manual keratometer. A
three-factor repeated measures analysis of variance with all factors r
epeated was performed using SAS and BMDP statistical software. Separat
e analyses were conducted for paracentral and peripheral data. To test
accuracy, measurements were taken with the Alcon EyeMap automatic foc
us system, the EyeSys System 2000, the Humphrey Atlas system, and the
Humphrey Mastervue system using four calibration spheres. Results. The
re were no statistically significant differences in the repeatability
of the instruments. The EyeSys corneal topography system had the most
narrow 95% limits of agreement around the mean difference. The two Hum
phrey instruments performed similarly to the EyeSys. Although the Alco
n EyeMap EH-290 had the widest 95% limits of agreement around the mean
difference, it showed better repeatability when the manual focus was
used compared with the automatic focus. The instruments varied in thei
r level of accuracy, but the highest percentage of data points within
+/-0.37 D of the known values of the calibration spheres was found wit
h the Humphrey Atlas. Conclusions. Although there were no statisticall
y significant differences in repeatability, the EyeSys System 2000 had
the highest repeatability, which may have clinical relevance. The acc
uracy measured in this study varied tremendously; however, the Humphre
y Atlas was found to be the most accurate of the instruments tested.