FINE-NEEDLE ASPIRATION CYTOLOGY OF FIBROUS DYSPLASIA - A CASE-REPORT

BACKGROUND: Fibrous dysplasia (FD) is a benign disorder of bone consis ting of intramedullary proliferation of fibrous tissue and irregularly distributed, poorly developed bone. Although tumorlike in appearence, FD is probably a condition resulting from failure of maturation from woven to lamellar bone. The histology of FD has been well characterize d sines Lichtenstein first reported it, in 1938; however, the cytologi c appearance has been described only rarely. To ours knowledge, this i s the first case report of fine needle aspiration (FNA) cytomorphology of FD. CASE: A 30-year-old female with breast carcinoma, diagnosed a month earlier, underwent computed tomography-guided FNA of a rib lesio n radiologically thought to represent FD, although metastatic cancer c ould not be excluded. The smears contained blood occasional osteoclast ic multinucleated giant cells and frequent C-shaped fibrillary structu res with dark central areas and lighter peripheries, representing wove n bane. The cytologic/radiologic impression of FD was confirmed histol ogically. CONCLUSION: FNA cyto-diagnosis of FD is possible it the sett ing of consistent clinical and radiologic findings.