ENZYME-ASSISTED PREPARATION OF PURE ALKANEDICARBOXYLIC ACID MONOESTERS - CHAIN-LENGTH DEPENDENCE OF PORCINE LIVER ESTERASE (PLE)-CATALYZED HYDROLYZES

Authors
LOBELL M SCHNEIDER MP
Citation
M. Lobell et Mp. Schneider, ENZYME-ASSISTED PREPARATION OF PURE ALKANEDICARBOXYLIC ACID MONOESTERS - CHAIN-LENGTH DEPENDENCE OF PORCINE LIVER ESTERASE (PLE)-CATALYZED HYDROLYZES, Journal of the Chemical Society. Perkin transactions. I, (15), 1993, pp. 1713-1714
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
15
Year of publication
1993
Pages
1713 - 1714
Database
ISI
SICI code
0300-922X(1993):15<1713:EPOPAA>2.0.ZU;2-D
Abstract
Porcine liver esterase (PLE)-catalysed hydrolyses of alkanedicarboxyli c esters MeO2C-(CH2)n-CO2Me lead exclusively to pure monoesters if n l ess-than-or-equal-to 7. Surprisingly, the yields are dramatically depe ndent on the chain length and drop sharply to zero for n greater-than- or-equal-to 8. Using the active site model for PLE an interpretation o f these surprising observations is attempted.