SYNTHETIC APPROACHES TOWARDS NUCLEOCIDIN AND SELECTED ANALOGS - ANTI-HIV ACTIVITY IN 4'-FLUORINATED NUCLEOSIDE DERIVATIVES

Authors
MAGUIRE AR MENG WD ROBERTS SM WILLETTS AJ
Citation
Ar. Maguire et al., SYNTHETIC APPROACHES TOWARDS NUCLEOCIDIN AND SELECTED ANALOGS - ANTI-HIV ACTIVITY IN 4'-FLUORINATED NUCLEOSIDE DERIVATIVES, Journal of the Chemical Society. Perkin transactions. I, (15), 1993, pp. 1795-1808
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
15
Year of publication
1993
Pages
1795 - 1808
Database
ISI
SICI code
0300-922X(1993):15<1795:SATNAS>2.0.ZU;2-2
Abstract
Nucleocidin 1 has been synthesised from the adenosine derivative 4 via the intermediacy of the dihalogeno compound 9. The latter compound sh owed slight but significant activity against HIV-infected cells while the isomer 10 and the monohalogeno compound 60 were inactive. Syntheti c approaches towards other 4'-fluorinated nucleoside derivatives are a lso described. The epimeric 4'-fluorinated nucleosides 26 and 27 displ ayed similar activity against HIV-infected cells to that observed for the dihalogenated compound 9.