EXHALED NITRIC-OXIDE AND BRONCHIAL REACTIVITY DURING AND AFTER INHALED BECLOMETHASONE IN MILD ASTHMA

The measurement of exhaled nitric oxide (ENO) is recognized as a marke r of airway inflammation. ENO was measured in 10 nonsteroid-treated as thmatics at recruitment, during 3 weeks of inhaled beclomethasone (100 0 mu g/day) and for 3 weeks after withdrawal. Baseline ENO was increas ed in asthma compared with nonasthmatics (85.0 +/- 54.5 vs. 24.5 +/- 1 4.8 ppb, p < 0.0001). After in haled steroid, there was no significant change in forced expiratory volume in 1 sec (FEV1) and forced vital c apacity (FVC), but methacholine PC20 rose significantly (p = 0.0345). ENO (mean +/- SD; % baseline) fell after 1 week on steroid to 60.6 +/- 31.1 and rose to 95.3 +/- 46.1 at 1 week after withdrawal. ENO did no t correlate with PC20 or FEV1. The changes in ENO and PC20 were invers ely correlated (r(2) = 0.325). ENO may be an index of airway inflammat ion and therapeutic response in bronchial asthma.