C-ERBB-2 HER-2 PROTEIN IN HUMAN INTRACRANIAL TUMORS/

Normal and neoplastic human intracranial tissues were examined by immu nohistochemistry for c-erbB-2/HER-2 protein expression. Positive stain ing was observed in 1/41 gliomas, 1/2 medulloblastomas, 1/1 germinoma, 11/16 meningiomas, 1/3 anaplastic meningiomas and 11/19 metastatic br ain carcinomas. No positive staining was observed in normal intracrani al tissues. Thus, the expression of the c-erbB-2/HER-2 protein is limi ted to intracranial tumour tissues, principally meningiomas and metast atic carcinomas to the brain.