Systemic lupus erythematosus (SLE) is a multi-system autoimmune disord
er that can affect the upper airway. Hydralazine has been known to cau
se a lupus-like syndrome that can produce the clinical manifestations
of SLE. We discuss a case of hydralazine-induced lupus, presenting wit
h acute laryngeal oedema and right vocal fold paralysis. Cessation of
hydralazine therapy resulted in reversal of paralysis.