More aggressive neurosurgical management of intractably elevated intra
cranial pressure has resulted in increased survival of severely brain
injured patients, many of whom are transferred for inpatient rehabilit
ation status post-craniectomy. Positional headache due to intracranial
hypotension has been described in the literature, but is rarely repor
ted as a complicating factor for patients receiving rehabilitation the
rapies. Low cerebrospinal fluid (CSF) pressure symptoms include postur
al headache, vertigo, nausea, vomiting, visual symptoms, auditory symp
toms, and rarely cognitive changes. This report describes a patient wh
o sustained a severe traumatic brain injury requiring craniectomy for
management of increased intracranial pressure who subsequently develop
ed intracranial hypotension. One month post-craniectomy, she developed
postural headaches with cognitive and functional decline, which signi
ficantly impaired her rehabilitation. Aggressive efforts at conservati
ve management including hydration and empiric blood patch were unsucce
ssful. Once the bone flap was replaced, she made rapid and dramatic fu
nctional gains, with total resolution of headache. This paper hypothes
izes that the mechanism of low CSF pressure after extensive craniectom
y is related to loss of hydrostatic pressure following removal of the
skull vault. Ln rehabilitation of severely brain injured patients with
craniectomies, it is important to recognize and appropriately treat t
his syndrome to avoid compromising patient care and prolonging hospita
lization.