NEW ACCESS TO ENANTIOPURE O,O'-DIBENZOYLTARTARIC ACID - RESOLUTION OFTHE MIXED CALCIUM METHOXYACETATE BY PREFERENTIAL CRYSTALLIZATION

Authors
ELEKES F KOVARI Z MRAVIK A BOCSKEI Z FOGASSY E
Citation
F. Elekes et al., NEW ACCESS TO ENANTIOPURE O,O'-DIBENZOYLTARTARIC ACID - RESOLUTION OFTHE MIXED CALCIUM METHOXYACETATE BY PREFERENTIAL CRYSTALLIZATION, Tetrahedron : asymmetry, 9(16), 1998, pp. 2895-2900
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
9
Issue
16
Year of publication
1998
Pages
2895 - 2900
Database
ISI
SICI code
0957-4166(1998)9:16<2895:NATEOA>2.0.ZU;2-0
Abstract
A convenient resolution of racemic O,O'-dibenzoyltartaric acid by pref erential crystallization of its mixed calcium salt formed with methoxy acetic acid is described. The separation of the partially prepared sal t 2 followed by a subsequent recrystallization results in a simple and effective resolution of the title compound during which pure enantiom ers of 1 can be obtained even on a large scale. The crystal structure of the conglomerate forming complex 2 is also reported. (C) 1998 Elsev ier Science Ltd. All rights reserved.