URINARY METABOLITES OF DAIDZIN ORALLY-ADMINISTERED IN RATS

Authors
YASUDA T OHSAWA K
Citation
T. Yasuda et K. Ohsawa, URINARY METABOLITES OF DAIDZIN ORALLY-ADMINISTERED IN RATS, Biological & pharmaceutical bulletin, 21(9), 1998, pp. 953-957
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Biological & pharmaceutical bulletin → ACNP
ISSN journal
09186158
Volume
21
Issue
9
Year of publication
1998
Pages
953 - 957
Database
ISI
SICI code
0918-6158(1998)21:9<953:UMODOI>2.0.ZU;2-0
Abstract
In a study on the metabolism of flavonoids, the isoflavone glycoside d aidzin was orally administered to rats. Urine samples were collected a nd treated,with beta-glucuronidase and arylsulfatase. Aglycone daidzei n (M3) and other three metabolites, 3',4',7-trihydroxyisoflavone (M1), 4',7-dihydroxyisoflavanone (M2) and 4',7-dihydroxyisoflavan (M4) were isolated from the urine following treatment with enzymes. The structu res of M1, M2 and M4 were determined on the basis of chemical and spec tral data.