DIRECT ENANTIOMERIC RESOLUTION OF RACEMIC MU-FCCCHCOW(CO)(5)(CPCOOC2H5) USING AMYLOPECTIN TRIS(PHENYLCARBAMATE) CHIRAL STATIONARY BY HPLC

Amylopectin tris(phenylcarbamate) was synthesized and used as the chir al stationary phase upon adsorbed over silica gel, For this purpose, a mylopectin was allowed to react with an excess of phenylisocyanate in pyridine for 48 h, The carbamate was dissolved and adsorbed on silica gel which had been treated with 3-aminopropyltriethoxysilane. The weig ht ratio of the carbamate to the silica gel was 0. 45 : 2. 55. The rac emic mu-FcC=CHCoW(CO)(5)(CpCOOC2H5) prepared from mu-FcC=HCo2(CO)(6) a nd (C2H5OOCCp)W(CO)(3)Na was resolved on this chiral stationary phase, Separation was carried out at room temperature, and methanol was used as the eluent at a flow rate of 0. 5 mL/min.