STUDIES ON SEMISYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 7-BETA-HETEROCYCLICAMIDO CEPHALOSPORINS

Nine new 7 beta-(1-aryl-5-methyl-1H-1,2, 3-triazolyl-4-formamido)cepha losporins 3a-3j were synthesized by acylation of 7 beta-amino group of 7-ACA, 7-ADCA and 7-ACT, with 1-aryl-5-methyI-1H-1, 2, 3-triazolyl-4- formyl chloride 2a-2c. Two new 7 beta-(1,2,5-benzotriazolyl-1-acetamid o) cephalosporins 6a-6b and two new 7 beta-(5-methyl isoxazolyl-3-form amido) cephalosporins 9a-9b were obtained with the same acid choride, Isolation and purification of the new compounds were fulfilled with Se phadex LH-20 column chromatography and centrifugal-TLC technique. The structure of the compounds were confirmed by elementary analysis, IR, H-1 NMR and FAB-MS, some of them showed a significant antibacterial ac tivity.