STUDIES ON ARTIFICIAL IMITATION OF GLUTATHIONE-PEROXIDASE BY USING SELENIUM-CONTAINING BETA-CYCLODEXTRIN - SYNTHESIS, PROPERTIES AND CHARACTERIZATION OF 6-SELENIUM BRIDGED BETA-CYCLODEXTRINS

Authors
LIU JQ NING YG SHI CB LUO GM YAN GL SHEN JC
Citation
Jq. Liu et al., STUDIES ON ARTIFICIAL IMITATION OF GLUTATHIONE-PEROXIDASE BY USING SELENIUM-CONTAINING BETA-CYCLODEXTRIN - SYNTHESIS, PROPERTIES AND CHARACTERIZATION OF 6-SELENIUM BRIDGED BETA-CYCLODEXTRINS, Gaodeng xuexiao huaxue xuebao, 19(9), 1998, pp. 1446-1448
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Gaodeng xuexiao huaxue xuebao → ACNP
ISSN journal
02510790
Volume
19
Issue
9
Year of publication
1998
Pages
1446 - 1448
Database
ISI
SICI code
0251-0790(1998)19:9<1446:SOAIOG>2.0.ZU;2-M
Abstract
6-Selenium bridged cyclodextrin was synthesized by regioselective tosy lation of beta-cyclodextrin and NaHSe displacement on the basis of the active site structure of glutathione peroxidase (GPX), The compounds displayed a higher activity of GPX than Ebselen (PZ51), its GPX activi ty was 4, 3 times more than that of PZ51, The structure of the mimic w as characterized by elemental analysis, IR and H-1 NMR, The Se content and its valence in the mimic was determined by X-ray photoelectron sp ectrum.