CISAPRIDE ENHANCES THE EFFECT OF PARTIAL POSTERIOR FUNDOPLICATION ON ESOPHAGEAL PERISTALSIS IN GERD PATIENTS WITH POOR ESOPHAGEAL CONTRACTILITY

Partial posterior fundoplication improves esophageal peristalsis in pa tients with gastroesophageal reflux disease (GERD) associated with poo r esophageal body function. The aim of this study was to investigate w hether postoperative administration of cisapride enhances the effect o f surgery on esophageal peristalsis. Laparoscopic partial posterior fu ndoplication was performed on 34 consecutive GERD patients with poor e sophageal body motility. These patients were randomized in groups with out and with postoperative treatment with cisapride 20 mg twice daily for six months. Esophageal manometry was performed preoperatively and six months following surgery. Esophageal body function improved signif icantly following partial posterior fundoplication without or with pos toperative treatment with cisapride. However, this effect was more pro nounced in the group of patients receiving cisapride. Partial posterio r fundoplication combined with postoperative treatment with cisapride should be the therapy of choice in GERD patients with poor esophageal body motility.