The present overview demonstrates that stress, fear, novelty, and lear
ning processes are associated with arousal and increases of extracellu
lar levels of cortical and hippocampal ACh, independently of increases
of motor activity. Forebrain cholinergic systems appear to be regulat
ed by GABAergic and glutamatergic inputs. However, several other neuro
transmitter systems play a role. ((C) Elsevier, Paris).