INFLUENCE OF RETINOIC ACID AND OF CYCLIC-AMP ON THE EXPRESSION OF CHOLINE-ACETYLTRANSFERASE AND OF VESICULAR ACETYLCHOLINE TRANSPORTER IN NG108-15 CELLS

Authors
DIEBLER MF TOMASI M MEUNIER FM ISRAEL M DOLEZAL V
Citation
Mf. Diebler et al., INFLUENCE OF RETINOIC ACID AND OF CYCLIC-AMP ON THE EXPRESSION OF CHOLINE-ACETYLTRANSFERASE AND OF VESICULAR ACETYLCHOLINE TRANSPORTER IN NG108-15 CELLS, J PHYSL-PAR, 92(5-6), 1998, pp. 379-384
Citations number
32
Categorie Soggetti
Physiology,Neurosciences
Journal title
JOURNAL OF PHYSIOLOGY-PARIS
ISSN journal
09284257 → ACNP
Volume
92
Issue
5-6
Year of publication
1998
Pages
379 - 384
Database
ISI
SICI code
0928-4257(1998)92:5-6<379:IORAAO>2.0.ZU;2-N
Abstract
Treatment of the cholinergic cell line NG108-15 with retinoic acid or cAMP results in an increase of choline acetyltransferase activity (ChA T) whereas none of these agents influences the amount of the vesicular acetylcholine transporter (VAChT) as judged from vesamicol binding an d immunoblot studies. We suggest that immaturity of posttranslational events controlling the expression of VAChT protein is responsible for the apparent absence of coregulation of ChAT and VAChT protein express ion. ((C) Elsevier, Paris).