2 BARRIER-1 SITE PORE - AN INTERACTIVE SPREADSHEET MODEL FOR 2 PERMEATING IONS

Authors
MANSOURA MK DAWSON DC
Citation
Mk. Mansoura et Dc. Dawson, 2 BARRIER-1 SITE PORE - AN INTERACTIVE SPREADSHEET MODEL FOR 2 PERMEATING IONS, Computers in biology and medicine, 28(3), 1998, pp. 255-273
Citations number
27
Categorie Soggetti
Computer Science Interdisciplinary Applications","Biology Miscellaneous","Computer Science Interdisciplinary Applications","Engineering, Biomedical
Journal title
Computers in biology and medicine → ACNP
ISSN journal
00104825
Volume
28
Issue
3
Year of publication
1998
Pages
255 - 273
Database
ISI
SICI code
0010-4825(1998)28:3<255:2BSP-A>2.0.ZU;2-P
Abstract
An interactive ion channel permeation tutorial was developed using a M icrosoft(R) Excel v5.0 spreadsheet to describe a two barrier, one site channel model by means of Eyring rate theory (ERT). The spreadsheet i s inherently interactive so that the user receives immediate feedback about how changes in the energy barrier profile or ion concentrations affect current-voltage relations and single channel conductance. The s preadsheet model is easy to use, allows direct access to intermediate calculated values and all equations, contains graphical displays of pa rameters and lends itself to customization by a user having only a bas ic knowledge of spreadsheet operations. (C) 1998 Elsevier Science Ltd. All rights reserved.