J. Bai et al., OPTIMIZATION AND MECHANISM OF STEP-LEAP RESPIRATION EXERCISE IN TREATING OF COR-PULMONALE, Computers in biology and medicine, 28(3), 1998, pp. 289-307
The interaction between cardiovascular system and the respiratory syst
em is complicated and may be used for the rehabilitation of the cor pu
lmonale disease. To study the effects of different breathing mode on t
he cardiac and pulmonary systems, a mathematical model is established
based on the previous work. Using this model, computer simulation expe
riments are carried out for searching an optimal respiration mode in t
reating of cor pulmonale disease. Results indicate that the step-leap
respiration mode could provide a better assistant to the rehabilitatio
n of the cor pulmonale patients in the sense of increasing coronary fl
ow, reducing pulmonary arterial pressure and reducing the working load
for the right heart. This result is also proven by the clinical exper
iments. This work may suggest that a proper directed respiration exerc
ise can be used in the treatment of cor pulmonale disease. (C) 1998 El
sevier Science Ltd. All rights reserved.