ANTIBACTERIAL TESTS OF BISMUTH(III)-QUINOLONE (CIPROFLOXACIN, CF) COMPOUNDS AGAINST HELICOBACTER-PYLORI AND SOME OTHER BACTERIA - CRYSTAL-STRUCTURE OF (CFH(2))(2)[BI2CL10]CENTER-DOT-4H(2)O

The antibacterial tests of two bismuth(III)-ciprofloxacin (cf) compoun ds against Helicobacter pylori (H. pylori) and some other bacteria wer e performed. The results have shown that the activity of both compound s is comparable to that of ciprofloxacin hydrochloride. The crystal st ructure of (CfH2)(2)[Bi2Cl10]. 4H(2)O (cfH(2) = doubly protonated mole cule of cf) is presented and discussed. The compound was isolated from acidic medium where quinolone is protonated and thus no bonding betwe en quinolone and bismuth was observed. The bismuth(III) ions are coord inated by chloride ions forming dinuclear [Bi2Cl10](4-) anions. The ch arge of this ion is compensated with protonated quinolone molecules (i onic interactions). (C) 1998 Elsevier Science Inc. All rights reserved .