POTENT ANTICONVULSANT PAEONIMETABOLIN-I DERIVATIVES OBTAINED BY INCUBATION OF PAEONIFLORIN AND THIOL COMPOUNDS WITH LACTOBACILLUS-BREVIS

Authors
ABDELHAFEZ AA MESELHY MR NAKAMURA N HATTORI M WATANABE H MOHAMED TA MAHFOUZ NM ELGENDY MA
Citation
Aa. Abdelhafez et al., POTENT ANTICONVULSANT PAEONIMETABOLIN-I DERIVATIVES OBTAINED BY INCUBATION OF PAEONIFLORIN AND THIOL COMPOUNDS WITH LACTOBACILLUS-BREVIS, Chemical and Pharmaceutical Bulletin, 46(9), 1998, pp. 1486-1487
Citations number
6
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
9
Year of publication
1998
Pages
1486 - 1487
Database
ISI
SICI code
0009-2363(1998)46:9<1486:PAPDOB>2.0.ZU;2-F
Abstract
Seventeen thiopaeonimetabolin-I adducts were obtained as mixtures of d iastereoisomers after incubation of paeoniflorin with Lactobacillus br evis in the presence of various thiols. Four compounds, 8-(n-hexylthio )- (8), 8-cyclopentylthio-, 8-(p-tolyl)thio- and 8-benzoylthio- (18) p aeonimetabolins, shelved 100% protection against pentylenetetrazole-in duced convulsions at doses of 0.125, 0.25, or 0.50 mmol/kg, relative t o valproic acid (100% protection at 1.5 mmol/kg). For 8 and 18, the pr inciple anticonvulsant activity resided in the (7S)-isomers while (7R) -isomers showed muscle relaxation effects.