FIRST-TRIMESTER SCREENING FOR DOWNS-SYNDROME USING MATERNAL SERUM PAPP-A AND FREE BETA-HCG IN COMBINATION WITH FETAL NUCHAL TRANSLUCENCY THICKNESS

Authors
BIAGIOTTI R BRIZZI L PERITI E DAGATA A VANZI E CARIATI E
Citation
R. Biagiotti et al., FIRST-TRIMESTER SCREENING FOR DOWNS-SYNDROME USING MATERNAL SERUM PAPP-A AND FREE BETA-HCG IN COMBINATION WITH FETAL NUCHAL TRANSLUCENCY THICKNESS, British journal of obstetrics and gynaecology, 105(8), 1998, pp. 917-920
Citations number
6
Categorie Soggetti
Obsetric & Gynecology
Journal title
British journal of obstetrics and gynaecology → ACNP
ISSN journal
03065456
Volume
105
Issue
8
Year of publication
1998
Pages
917 - 920
Database
ISI
SICI code
0306-5456(1998)105:8<917:FSFDUM>2.0.ZU;2-M
Abstract
The aim of this study was to evaluate the potential effectiveness of m aternal serum pregnancy-associated plasma protein A (PAPP-A) and free beta-hCG in combination with nuchal translucency thickness in first tr imester screening for Down's syndrome. Maternal serum levels of PAPP-A and free beta-hCG were assayed in stored sera from 32 Down's syndrome and 200 unaffected pregnancies. Fetal nuchal translucency was measure d by ultrasound at the time of blood sampling. Screening of Down's syn drome using a combination of maternal age, PAPP-A, free beta-hCG and n uchal translucency would achieve a detection rate of 75.8% for a false positive rate of 5%.