SURGICAL REMOVAL OF EXTENSIVE PERIPAPILLARY CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH PRESUMED OCULAR HISTOPLASMOSIS SYNDROME

Objective: This study aimed to report the visual outcome of surgical r emoval of extensive peripapillary choroidal neovascularization (CNV) d ue to presumed ocular histoplasmosis syndrome (POHS). Design: Retrospe ctive review of the records of all patients seen at the Barnes Retina Institute who underwent surgical removal of extensive peripapillary CN V associated with POHS and who had at least 12 months of follow-up. Pa rticipants: Seventeen consecutive eyes (in 14 patients) undergoing sur gical removal of extensive peripapillary CNV associated with POHS were studied. Intervention: Pars plana vitrectomy and surgical removal of CNV were performed. Main Outcome Measurements: Best-corrected Snellen visual acuity, funduscopic examination, and intravenous fluorescein an giography were obtained before surgery and at regular intervals after surgery. Results: In 14 of 17 eyes, the peripapillary CNV was subfovea l, and in 3 eyes, it was extrafoveal. All three eyes with extrafoveal CNV were not eligible for laser treatment according to Macular Photoco agulation Study guidelines because treatment would have spared less th an 1.5 contiguous clock-hours of retina temporal to the optic disc. Fo llow-up ranged from 17 to 57 months, with a median of 32 months. In ey es with subfoveal CNV, best-corrected preoperative Snellen visual acui ty ranged from 20/25 to counting fingers at 2 feet with a median of 20 /200, and best-corrected final Snellen visual acuity ranged from 20/25 to 20/200 with a median of 20/40. In 7 (50%) of 14 eyes, a final Snel len acuity of 20/40 or better was achieved, and in all cases except 1, visual acuity improved or did not change with surgery. In the three e yes with extrafoveal CNV, best-corrected preoperative Snellen visual a cuity ranged from 20/20 to 20/400 with a median of 20/200, and best-co rrected final Snellen visual acuity was 20/20 in all cases. In additio n, visual acuity improved with surgery. Conclusions The data from this small retrospective study suggest that surgical removal may provide v isual benefit in selected cases of extensive peripapillary CNV due to POHS.