We report a 39-year-old man with a history of recurrent deep venous th
rombosis (DVT) whose only laboratory-identified risk factor was modera
te hyperhomocysteinaemia. After being lost to follow-up without interv
ention, he presented with another DVT: Apart from standard anticoagula
tion therapy he received vitamin supplementation (folate and vitamin B
-12), which normalised his elevated plasma homocysteine level. Moderat
e hyperhomocysteinaemia is a relatively common abnormality and an easi
ly modifiable risk factor for DVT.