A CLOSE FAMILY RESEMBLANCE - THE IMPORTANCE OF STRUCTURE IN UNDERSTANDING CYTOCHROMES P450

Authors
PETERSON JA GRAHAM SE
Citation
Ja. Peterson et Se. Graham, A CLOSE FAMILY RESEMBLANCE - THE IMPORTANCE OF STRUCTURE IN UNDERSTANDING CYTOCHROMES P450, Structure, 6(9), 1998, pp. 1079-1085
Citations number
28
Categorie Soggetti
Biophysics,Biology,"Cell Biology
Journal title
Structure → ACNP
ISSN journal
09692126
Volume
6
Issue
9
Year of publication
1998
Pages
1079 - 1085
Database
ISI
SICI code
0969-2126(1998)6:9<1079:ACFR-T>2.0.ZU;2-M
Abstract
Cytochromes P450 comprise a very large superfamily of hemeproteins whi ch generally monooxygenate hydrophobic compounds. P450s appear to have a common conserved structural core, yet are variable in regions invol ved in substrate recognition and binding, and in redox-partner binding . These differences can be identified by an analysis in which structur al alignments and homology models are used to compare the various clas ses and families of P450s.