EFFICIENT SYNTHESIS OF N-ARYLPIPERAZINONES VIA A SELECTIVE INTRAMOLECULAR MITSUNOBU CYCLODEHYDRATION

Authors
WEISSMAN SA LEWIS S ASKIN D VOLANTE RP REIDER PJ
Citation
Sa. Weissman et al., EFFICIENT SYNTHESIS OF N-ARYLPIPERAZINONES VIA A SELECTIVE INTRAMOLECULAR MITSUNOBU CYCLODEHYDRATION, Tetrahedron letters, 39(41), 1998, pp. 7459-7462
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
41
Year of publication
1998
Pages
7459 - 7462
Database
ISI
SICI code
0040-4039(1998)39:41<7459:ESONVA>2.0.ZU;2-C
Abstract
A practical two pot synthesis of N-arylpiperazinones from the correspo nding aniline is described. The key transformation is a selective intr amolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%. (C ) 1998 Elsevier Science Ltd. All rights reserved.