SELECTIVE PALLADIUM-MEDIATED SYNTHESIS OF RACEMIC 4,5-DISUBSTITUTED 5H-FURAN-2-ONES FROM 3-YNOIC ACIDS AND ORGANIC HALIDES

Authors
ROSSI R BELLINA F BIAGETTI M MANNINA L
Citation
R. Rossi et al., SELECTIVE PALLADIUM-MEDIATED SYNTHESIS OF RACEMIC 4,5-DISUBSTITUTED 5H-FURAN-2-ONES FROM 3-YNOIC ACIDS AND ORGANIC HALIDES, Tetrahedron letters, 39(41), 1998, pp. 7599-7602
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
41
Year of publication
1998
Pages
7599 - 7602
Database
ISI
SICI code
0040-4039(1998)39:41<7599:SPSOR4>2.0.ZU;2-9
Abstract
Racemic 4,5-disubstitued 5H-furan-2-ones have been selectively synthes ized by addition of 1.2-1.6 equiv of aryl, alkenyl or 1-alkynyl halide s and catalytic amounts of Pd(OAc)(2) and a soft ligand such as tri-2- furylphosphine or triphenylarsine to the reaction mixtures obtained by treatment of 3-ynoic acids with 1.1 equiv of t-BuOK in DMSO at 20 deg rees C. (C) 1998 Elsevier Science Ltd. All rights reserved.