ENHANCED IMMUNE-RESPONSES AND RESISTANCE AGAINST INFECTION IN AGED MICE CONFERRED BY FLU-ISCOMS VACCINE CORRELATE WITH UP-REGULATION OF COSTIMULATORY MOLECULE CD86

Authors
SAMBHARA S KURICHH A MIRANDA R TAMANE A ARPINO R JAMES O MCGUINNESS U KANDIL A UNDERDOWN B KLEIN M BURT D
Citation
S. Sambhara et al., ENHANCED IMMUNE-RESPONSES AND RESISTANCE AGAINST INFECTION IN AGED MICE CONFERRED BY FLU-ISCOMS VACCINE CORRELATE WITH UP-REGULATION OF COSTIMULATORY MOLECULE CD86, Vaccine, 16(18), 1998, pp. 1698-1704
Citations number
25
Categorie Soggetti
Veterinary Sciences",Immunology,"Medicine, Research & Experimental
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
16
Issue
18
Year of publication
1998
Pages
1698 - 1704
Database
ISI
SICI code
0264-410X(1998)16:18<1698:EIARAI>2.0.ZU;2-1
Abstract
Ageing is associated with a decline in immune function and our primary objective is to 'reverse' age-related decline in. protective immune r esponses to vaccination by formulating vaccines in appropriate deliver y systems. In this paper we demonstrate that influenza vaccine formula ted as ISCOMs is highly immunogenic and confers protection in aged mic e, when compared to current influenza vaccine. The enhanced protection conferred by Flu-ISCOMs in aged mice correlates with the up-regulatio n of co-stimulatory molecule, CD86 (B7.2) and to a lesser extent, CD80 (B7.2) expression on antigen presenting cells. (C) 1998 Elsevier Scie nce Ltd. All rights reserved.